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Improving the transparency, reproducibility, and trustworthiness of science

I am an associate professor of neuroscience at Karolinska Institutet, a researcher at Stockholm University. I am further affiliated to the METRICS center at Stanford University and I collaborate closely with the QUEST Center in Berlin where I was recently a visiting fellow. I am a national coordinator of domain specialists with the Swedish National Data Service, a role which entails promoting data sharing in science through education, advocacy, and providing resources. Since 2017 I teach a PhD course in open science and reproducible research at Karolinska Institutet. I am co-chair of the EOSC Association task force on researcher careers, recognition and credit, and a member of numerous committees and groups working on open science and research assessment.


I work in metascience to assess and improve transparency and reproducibility of research using quantitative methods. Particular interests include multi-analyst designs, quality control and error checking, researchers’ incentives, and evidence synthesis.


My research in neuroscience concerns mainly sleep, diurnal rhythms, and markers of inflammation. For many years I ran a research programme involving experimental studies of sleep deprivation using brain imaging. Currently I am working mainly on projects aiming to collect large amounts of existing data for secondary analysis. The discovery I feel most proud of is that interleukin-6, a signalling molecule of the immune system, does not increase in the blood of healthy humans at night, as previously thought; this disproves a role for interleukin-6 as a sleep regulatory substance mediated by the blood.


Together with colleagues, I run projects to assess biomarkers in psychiatry and to develop better ways to predict interventions for patients.

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